منابع مشابه
Death by Deamination A Novel Host Restriction System for HIV-1
A human gene with potent antiretroviral activity has recently been found to encode a new member of the family of cytidine deaminases, previously known to be involved in mRNA editing, immunoglobulin gene class switching, and immunoglobulin gene hypermutation. The enzyme attacks viral DNA as it is synthesized in infected cells and prevents the formation of functional proviruses. The Vif gene of H...
متن کاملDNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B
APOBEC (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like) is a family of enzymes that deaminates cytosine (C) to uracil (U) on nucleic acid. APOBEC3B (A3B) functions in innate immunity against intrinsic and invading retroelements and viruses. A3B can also induce genomic DNA mutations to cause cancer. A3B contains two cytosine deaminase domains (CD1, CD2), and there are conflictin...
متن کاملDeamination of amino acids by Clostridium botulinum.
The types of Clostridium botulinum were found to differ in their abilities to deaminate single amino acids. Cells were prepared from 24to 36-hr cultures grown at 37 C in screw-cap tubes in a medium containing (grams per liter); Trypticase (BBL), 15; Phytone (BBL), 5; yeast extract, 5; K2HP04, 8.5; KH2PO4, 1.5; NaCl, 1; MgSO4. 7H20, 0.25; FeSO4.7H20, 0.0125; and sodium thioglycolate, 1. The cell...
متن کاملDeamination of serine. I. Catalytic deamination of serine and cysteine by pyridoxal and metal salts.
In an investigation of transamination reactions between pyridoxal and amino acids at 100” (2) serine was found to behave anomalously, apparently being deaminated to pyruvic acid with little change in pyridoxal concentration. Although serine is known to be deaminated by hot concentrated alkalies (3) and acids (4), such a non-enzymatic reaction in the pH range near neutrality has not been reporte...
متن کاملDeamination of Serine I. Catalytic Deamination of Serine and Cysteine by Pyridoxal and Metal Salts* by David E. Metzler
In an investigation of transamination reactions between pyridoxal and amino acids at 100” (2) serine was found to behave anomalously, apparently being deaminated to pyruvic acid with little change in pyridoxal concentration. Although serine is known to be deaminated by hot concentrated alkalies (3) and acids (4), such a non-enzymatic reaction in the pH range near neutrality has not been reporte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00602-0